How to manually remove Spywares?

What if Anti-Spyware tools fails to remove spyware from your PC? Are there any tools that you could run to see whats infect in your PC? Fortunately there many.

Protect yourself from Rogue Anti-Spyware Software

There are numerous fake or rogue anti-spyware programs that are waiting to infect your computer. How do you protect yourself from them? Are there any legitimate Anti-Spyware tools available?